Combination vaccines with whole cell pertussis antigen

摘要

Vaccines have been studied that comprise (a) D-T-Pw-HepB-Hib antigens and (b) one or more meningococcal conjugate antigens. A number of improvements and variations of these vaccines have been discovered. The vaccines can be prepared extemporaneously at the time of use by mixing together two components: (a) a first component comprising D, T, wP and HBsAg antigens; and (b) a second component comprising a Hib conjugate and one or more meningococcal conjugates.

主权项

1. A vaccine composition comprising:
(i) a diphtheria toxoid, ‘D’; (ii) a tetanus toxoid, ‘T’; (iii) a cellular pertussis antigen, ‘wP’; (iv) a hepatitis B virus surface antigen, ‘HBsAg’; (v) a Haemophilus influenzae type b (‘Hib’) capsular saccharide conjugated to a carrier protein; and (vi) at least one Neisseria meningitidis capsular saccharide conjugated to a carrier protein, wherein the at least one Neisseria meningitidis capsular saccharide comprises an O-acetyl (OAc+) Neisseria meningitidis serogroup C capsular saccharide, wherein the H. influenzae type b capsular saccharide and the N. meningitidis capsular saccharide(s) are each conjugated to a tetanus toxoid carrier protein, or the N. meningitidis capsular saccharide(s) is conjugated to a tetanus toxoid, diphtheria toxoid, or CRM197 carrier protein, and wherein the conjugate of component (v) has a weight excess of carrier, and wherein the weight ratio of saccharide to carrier is between 1:2 and 1:4.