MÉTODO PARA PRODUZIR FATOR DE VON WILLEBRAND MADURO A PARTIR DE PRÓ-PEPTÍDEO DE FATOR DE VON WILLEBRAND, USO DE UM FATOR DE VON WILLEBRAND MADURO, E, MÉTODO PARA TRATAR DOENÇA DE VON WILLEBRAND EM UM MAMÍFERO

摘要

The present invention relates to a method for producing a mature von Willebrand Factor (VWF) from von Willebrand Factor pro-peptide comprising the steps: immobilizing VWF pro-peptide on an ion exchange resin, incubating the immobilized VWF pro-peptide with furin to obtain immobilized mature VWF, and isolating mature VWF from the ion exchange resin by elution.