Topical antifungal compositions and methods of use thereof

摘要

Described herein are compositions and methods that treat fungal infections of the skin, reduce the severity and duration of symptoms of fungal infections of the skin, and prevent recurrence of fungal infections. The topical compositions described herein are creamy pastes composed of an admixture of an imidazole antifungal and nystatin. The topical compositions can also include optional fillers. The compositions and methods described herein minimize fungal resistance and maximize the number of targeted fungal strains. Additionally, the compounds and methods do not suppress the body's immune system either locally or systemically, thus allowing for a faster restoration of normal skin flora. The compositions and methods described herein are particularly suitable for use in infants and children as well as in immunocompromised individuals, diabetics, and the obese.

主权项

1. A topical paste comprising
(a) 1% clotrimazole cream and (b) nystatin powder comprising an inert powder having an activity of 100,000 units/gm, wherein the weight ratio of clotrimazole cream to nystatin powder is from 1:1 to 5:1 to form a paste comprising granular particles evenly distributed in the topical paste, and wherein the clotrimazole cream and nystatin powder are the only bioactive agents in the topical paste.