Saporin-L1 inhibitors and uses thereof

摘要

Inhibitors of saporin-L1 are disclosed, as are related compositions and uses thereof, in particular in cancer therapy that employs saporin-L1-linked immunotoxins.

主权项

1. A transition state inhibitor of saporin-L1 selected from the group consisting of:
an inhibitor having the structure: wherein each R is independently OCH3 or aryl or alkyl, where the aryl or alkyl can be optionally substituted with one or more of OH, ═O, OCH3, NH2, C1-C6 alkyl or halogen; or a pharmaceutically acceptable salt thereof; an inhibitor having the structure: or a pharmaceutically acceptable salt thereof; an inhibitor having the structure: or a pharmaceutically acceptable salt thereof; an inhibitor having the structure: or a pharmaceutically acceptable salt thereof; an inhibitor having the structure: or a pharmaceutically acceptable salt thereof; an inhibitor having the structure: or a pharmaceutically acceptable salt thereof; and an inhibitor having the structure: or a pharmaceutically acceptable salt thereof.