发明名称 |
Water-soluble pharmaceutical compositions of hops resins |
摘要 |
The present invention is drawn to water-soluble compositions for providing hops constituents, particularly alpha acids, iso-alpha acids, and beta acids. A pharmaceutical gel composition can comprise a hops extract and a surfactant. Such compositions can be formulated into products for various therapeutic applications, including oral and topical uses. Such compositions can also be dissolved in water to yield a clear solution containing more dilute hops acids. The invention also provides methods of treatment comprising administering water-soluble hops compositions. The present invention is also drawn to methods for making water-soluble preparations of hops constituents. |
申请公布号 |
US8883225(B2) |
申请公布日期 |
2014.11.11 |
申请号 |
US201313736513 |
申请日期 |
2013.01.08 |
申请人 |
Bioactives, Inc. |
发明人 |
Kuhrts Eric H. |
分类号 |
A01N65/00;A61K8/35;A61Q5/10;A61K8/60;A61K31/122;A61K8/97;A61K8/86;A61Q11/00;A61K36/185;A61K8/04 |
主分类号 |
A01N65/00 |
代理机构 |
Thorpe North & Western LLP |
代理人 |
Thorpe North & Western LLP |
主权项 |
1. A method of making a water-soluble pharmaceutical gel composition of isomerized hops extract, comprising the steps:
heating a water-soluble non-ionic surfactant in a container to a temperature of about 90° F. to about 250° F., while mixing the non-ionic surfactant until it is clear, wherein the non-ionic surfactant is selected from the group consisting of monoglycerides, diglycerides, triglycerides, mono-fatty acid esters of polyethylene glycol, di-fatty acid esters of polyethylene glycol, sorbitan fatty acid esters, polyglycolyzed glycerides, triblock copolymers, and mixtures thereof; heating a hops extract to a temperature of about 120° F. to 250° F. such that isomerization of the hops extract occurs to yield isomerized hops; and mixing an amount of the hops extract which includes the isomerized hops extract with the non-ionic surfactant so as to yield from 0.2 wt % to 70 wt % hops extract which includes the isomerized hops extract and from 30 wt % to 99.8 wt % non-ionic surfactant, wherein the hops extract which includes the isomerized hops extract is sufficiently dispersed or dissolved in the non-ionic surfactant to yield the water-soluble pharmaceutical gel composition of isomerized hops extract which contains no visible particles. |
地址 |
Bodega CA US |