| 发明名称 | Compositions and methods for antibodies targeting complement protein C5 | ||
| 摘要 | The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof. | ||
| 申请公布号 | US8883158(B2) | 申请公布日期 | 2014.11.11 |
| 申请号 | US201213557562 | 申请日期 | 2012.07.25 |
| 申请人 | Novartis AG | 发明人 | Diefenbach-Streiber Beate;Eberth Adina;Guild Braydon Charles;Kim Yong-In;Roguska Michael;Splawski Igor |
| 分类号 | A61K39/395;C07K16/18;C07K16/46 | 主分类号 | A61K39/395 |
| 代理机构 | Novartis Institutes for BioMedical Research, Inc. | 代理人 | Novartis Institutes for BioMedical Research, Inc. |
| 主权项 | 1. An isolated antibody or an antigen binding fragment thereof that specifically binds to a human complement C5 protein, said antibody or antigen binding fragment thereof comprising a HCDR1 sequence comprising the sequence of SEQ ID NO: 17, a HCDR2 sequence comprising the sequence of SEQ ID NO: 18, a HCDR3 sequence comprising the sequence of SEQ ID NO: 19, a LCDR1 sequence comprising the sequence of SEQ ID NO: 20, a LCDR2 sequence comprising the sequence of SEQ ID NO: 21, and a LCDR3 sequence comprising the sequence of SEQ ID NO: 22. | ||
| 地址 | Basel CH | ||