METHOD OF SCREENING A SUBSTANCE CAPABLE OF INHIBITING INTERACTION BETWEEN PRP19 AND CLIC PROTEINS AND A COMPOSITION COMPRISING THE SCREENED SUBSTANCE

摘要

The present invention relates to a method for searching for a substance which inhibits an interaction between precursor RNA processing (PRP) 19 proteins and intracellular chloride channel (CLIC) proteins and to a cosmetic composition or a pharmaceutical composition which contains an Elaeocarpus extract searched through the method as an active ingredient. According to the present invention, the substance which inhibits an interaction between PRP19 proteins and CLIC proteins can be rapidly searched on a large scale. The substances searched for through the method of the present invention can inhibit the generation of fat so as to be usefully applied in treating and preventing obesity and diseases which are mediated by an interaction between PRP19 proteins and CLIC proteins.