主权项 |
1. A melampomagnolide B derivative compound of the formula (I): wherein: R is selected from —P(O)(OR1)(OR2); —CH2OP(O)(OR1)(OR2); —C(O)(CR3R4)nX; —CH2OC(O)(CR3R4)nX; —C(O)O(CR3R4)nX; —C(O)NHCH2CH2NH2; —C(O)NHCH2(CH2)2NH2; —C(O)NHCH2(CH2)3NH2; —C(O)NHCH2(CH2)4NH2 and —C(O)(CH2)mC(O)NH(CR3R4)nX; R1, R2 are independently selected from H; Na; K; NH3; unsubstituted C1-C12alkyl, optionally substituted alkenyl, alkynyl, heterocycloalkyl, heteroaryl, cycloalkyl, and aryl; R3, R4 are independently selected from H, NR5R6, OR1, SR1, S(O)R1, SO2R1, optionally substituted C1-C12alkyl, alkenyl, alkynyl, heterocycloalkyl, heteroaryl, cycloalkyl, and aryl; R5, R6 are independently selected from H; optionally substituted C1-C12alkyl, alkenyl, alkynyl, heterocycloalkyl, heteroaryl, cycloalkyl, aryl; —CO2C1-C12alkyl, CO2alkenyl, CO2alkynyl, CO2heterocycloalkyl, CO2heteroaryl, CO2cycloalkyl, CO2aryl; and C1-C12alkylamino; or R5 and R6 optionally together with the nitrogen atom form an optionally substituted 5-12 membered ring, said ring optionally comprising 1 or more heteroatoms; X is selected from NR5R6, NHC(O)R2; NHC(O)OR2; OR1, SR1, halo, trifluoromethyl, optionally substituted C1-C12alkyl, alkenyl, alkynyl, heterocycloalkyl, heteroaryl, cycloalkyl, and aryl; n is 1-6, m is 1-2; or a pharmaceutically acceptable salt or ester thereof. |