Composition containing microRNA-21 inhibitor for enhancing radiation sensitivity

摘要

Disclosed is a radiation sensitivity-enhancing composition in which a microRNA-21 inhibitor acts as an active ingredient. The microRNA-21 inhibitor is an antisense nucleic acid molecule binding complementarily to microRNA-21. The composition can be administered to a patient in conjunction with irradiation. The inhibitor can act as a radiosensitizer, enhancing the therapeutic effect of such irradiation on cancer high in microRNA-21 expression level, particularly, glioma.

主权项

1. A method of treating a cancer with radiotherapy, comprising (a) administering to an animal a therapeutically effective amount of a composition comprising a microRNA-21 inhibitor to enhance radiation sensitivity of the cancer, and (b) exposing the animal to radiation,
wherein the cancer is (i) high in microRNA-21 expression level and radiation resistance, and (ii) selected from the group consisting of glioma, breast cancer, lung cancer, and uterine cancer, and wherein the microRNA-21 inhibitor is an antisense nucleic acid molecule comprising the nucleotide sequence set forth in SEQ ID NO: 1.