发明名称 CRYSTALLINE FORM OF AN INHIBITOR OF MDM 2/4 AND P53 INTERACTION
摘要 <p>A crystalline form of (S)-1-(4-Chloro-phenyl)-7-isopropoxy-6-methoxy-2-(4-{methyl-[4-(4- methyl-3-oxo-piperazin-1-yl)-trans-cyclohexylmethyl]-amino}-phenyl)-1,4dihydro-2H- isoquinolin-3-one, which is useful in the treatment of a disease or disorder associated with the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively, (I).</p>
申请公布号 TN2013000194(A1) 申请公布日期 2014.11.10
申请号 TN20130000194 申请日期 2013.05.03
申请人 NOVARTIS AG 发明人 BERGHAUSEN JOERG;REN HAIXIA
分类号 A61K31/495;A61P35/00;C07D401/12 主分类号 A61K31/495
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