| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a method of obtaining a polymer conjugate of an indolocarbazole compound of formula(I), where R, R, R, Wand Wrepresent hydrogen, X represents methoxy-polyethyleneglycol. The method includes the interaction of a polymer compound of formula (II)with an indolocarbazole compound of formula(III), where Y stands for a methoxygroup. The nvention also relates to a polymer conjugate of formula (I), a pharmaceutical composition, containing the conjugate of formula (I) as an active ingredient, and to the application of the polymer conjugate of formula (I).EFFECT: obtaining the polymer conjugate of the formula with a high output, the polymer conjugate of the formula for treatment of skin pathologies and HMGB1-associated pathologies.48 cl, 7 dwg, 7 tbl, 15 ex |
