| 发明名称 |
PROCESS FOR ALKYNYLATING 16-SUBSTITUTED-17-KETO STEROIDS |
| 摘要 |
A process ethynylates 16-methylene-17-keto steroids to the corresponding 16-methylene-17α-ethynyl-17&bgr;-hydroxy steroids by treatment with silyl-protected lithium acetylides followed by further desilylation. The resulting products are useful intermediates in the preparation of several pharmaceutically active agents, such as e.g. Nestorone® or melengestrol acetate. |
| 申请公布号 |
KR20140130425(A) |
申请公布日期 |
2014.11.10 |
| 申请号 |
KR20147020581 |
申请日期 |
2012.12.19 |
| 申请人 |
CRYSTAL PHARMA, S.A.U.;THE POPULATION COUNCIL, INC. |
发明人 |
GUTIERREZ FUENTES LUIS GERARDO;SANDOVAL RODRIGUEZ CELSO MIGUEL |
| 分类号 |
C07J7/00;A23L29/20;C07J75/00 |
主分类号 |
C07J7/00 |
| 代理机构 |
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