NUCLEIC ACID VACCINES AGAINST HERPES SIMPLEX VIRUS TYPE 2: COMPOSITIONS AND METHODS FOR ELICITING AN IMMUNE RESPONSE

摘要

Herpes Simplex Virus-2 (HSV-2) infection is a major health concern. The present disclosure provides, inter alia, certain highly effective vaccines and immunogenic compositions against HSV-2. The antigens can be used therapeutically or prophylactically.

主权项

1. A vaccine formulation comprising a pharmaceutically-acceptable carrier, an adjuvant, and a nucleic acid having a nucleotide sequence that encodes at least one of the polypeptides having SEQ ID NOS: 1, 3, 5, 38, or 138, or an immunogenic fragment thereof.