T-CELL ANTIGEN PEPTIDE FROM ALLERGEN FOR STIMULATION OF IL-10 PRODUCTION

摘要

A first or second polypeptide for use in a method of treating or preventing a disorder by tolerisation, wherein said method comprises administration of the first and second polypeptide; and wherein both first and second polypeptides:
i) are of 7 to 30 amino acids in length;ii) comprise at least one MHC Class II-binding T cell epitope; andiii) are a fragment of a protein allergen or a homologous variant of said fragment;wherein said first polypeptide induces the release of an amount of IL-10 that is greater than the amount of IL-10 released in response to the whole protein allergen from which the first polypeptide derives;wherein said disorder is characterised by an inappropriate immune response to the protein allergen from which the second polypeptide derives.

主权项

1. A method of treating ragweed allergy comprising administering to a subject in need thereof a therapeutically effective amount of a polypeptide which:
(i) consists of the sequence of KGEAAIKLTSSAGVLSKK (SEQ ID NO: 20; RGW07D); or (ii) is a longer peptide of up to 30 amino acids in length comprising the sequence of RGW07D; (iii) is a variant of RGW07D having at least 90% homology thereto; (iv) is a variant of RGW07D comprising one or two amino acid substitutions; or (v) is a fragment of RGW07D derived by removal of one or two amino acids from the N- or C-terminal ends thereof, or by removal of one amino acid from the N-terminal end thereof and one amino acid from the C-terminal end thereof.