发明名称 |
METHOD OF TREATING ANKYLOSING SPONDYLITIS |
摘要 |
The invention provides methods, uses and compositions for the treatment of ankylosing spondylitis (AS). The invention describes methods and uses for treating ankylosing spondylitis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to reduce signs and symptoms of ankylosing spondylitis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment of ankylosing spondylitis in a subject. |
申请公布号 |
US2014328855(A1) |
申请公布日期 |
2014.11.06 |
申请号 |
US201414306658 |
申请日期 |
2014.06.17 |
申请人 |
Wong Robert L. |
发明人 |
Wong Robert L. |
分类号 |
C07K16/24 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating active ankylosing spondylitis (AS) in a subject having total spinal ankylosis comprising selecting a subject having active AS and total spinal ankylosis, and subcutaneously administering 40 mg of an isolated human anti-TNFα antibody to the subject once every other week, wherein the human anti-TNFα antibody comprises a light chain variable region (LCVR) comprising the amino acid sequence of SEQ ID NO: 1, and comprises a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO: 2. |
地址 |
Basking Ridge NJ US |