| 摘要 |
Compounds and compositions for the treatment of bone disorders are presented. Oxysterol compounds and compositions for the treatment of bone disorders are presented. The compounds are conjugates or derivatives of (3S,5S,6S,8R,9S,10R,13S,14S,17S)-17-[(2S)-2-hydroxyoctan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17- tetradecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol with a BTA-linker, such as from a tetracycline fragment, attached to 3-position, 6-position, or 20-position. These osteogenic oxysterol compounds stimulate hedgehog signaling pathway. The various linker units are susceptible to certain esterases. |
