| 发明名称 |
MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS |
| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide modulators of ATP-binding cassette ("ABC") transporters, and methods of treating ABC transporter mediated diseases using the same.SOLUTION: Compounds of the present invention and pharmaceutically acceptable compositions thereof are useful as modulators of ATP-binding cassette ("ABC") transporters or fragments thereof, including cystic fibrosis transmembrane conductance regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using the compounds of the present invention.</p> |
| 申请公布号 |
JP2014208719(A) |
申请公布日期 |
2014.11.06 |
| 申请号 |
JP20140165547 |
申请日期 |
2014.08.15 |
| 申请人 |
VERTEX PHARMACEUTICALS INC |
发明人 |
RUAH SARA S HADIDA;GROOTENHUIS PETER D J;VAN GOOR FREDERICK;MILLER MARK T;MCCARTNEY JASON;ZHOU JINGLAN;BEAR BRIAN;NUMA MEHDI MICHEL JAMEL |
| 分类号 |
C07D405/12;A61K31/404;A61K45/00;A61P3/00;A61P3/06;A61P3/10;A61P5/14;A61P5/16;A61P7/04;A61P7/12;A61P9/00;A61P11/00;A61P19/04;A61P19/08;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P35/00;A61P43/00 |
主分类号 |
C07D405/12 |
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