The factor H binding activity of meningococcal fHBP can be uncoupled from its bactericidal sensitivity. NMR studies have identified various amino acid residues involved in the fHBP/fH interaction and one or more of these residues is modified in a fHBP to reduce or eliminate its ability to bind to fH.
申请公布号
AU2010310985(B2)
申请公布日期
2014.11.06
申请号
AU20100310985
申请日期
2010.10.27
申请人
NOVARTIS AG
发明人
BANCI, LUCIA;CANTINI, FRANCESCA;DRAGONETTI, SARA;GENTILE, MARIA ANTONIETTA;VEGGI, DANIELE;SCARSELLI, MARIA;PIZZA, MARIAGRAZIA
