| 主权项 |
1. An in vitro method for diagnosis of liver cirrhosis in a patient comprising the steps of:
a) measuring the values of at alpha2-macroglobulin, haptoglobin, apolipoprotein-A1, total bilirubin, gamma-glutamyl-transpeptidase (GGT) in the serum or plasma of said patient, and combining said values through a first logistic function including said markers, the age and sex of said patient, wherein said first logistic function is 4.467×Log(Alpha2Macroglobulin (g/l))−1.357×Log(Haptoglobin (g/l))+1.017×Log(GGT (IU/l))+0.0281×Age (in years)+1.737×Log(Bilirubin (μmol/l))−1.184×ApoA1 (g/l)+0.301×Sex (female=0, male=1)−5.540, and obtaining a first index b) measuring liver stiffness for said patient by Vibration Controlled Transient Elastography and obtaining a second index c) combining said first and second index through a second logistic function in order to obtain a final index, wherein said second logistic function is a1+a2×[first index]+a3×[second index] wherein a1 is comprised between −9.27 and −9.07; a2 is comprised between 3.08 and 3.1; a3 is comprised between 5.67 and 5.87. |
