ANTIBODIES THAT BIND OV064 AND METHODS OF USE THEREFOR

摘要

Antibodies and antigen-binding fragments of antibodies that bind OV064 are disclosed. The antibodies bind an extracellular domain of OV064. Some of the antibodies and antigen-binding fragments bind an epitope on OV064 sufficient to induce internalization. In some embodiments, the antibodies are humanized, chimeric or human. Nucleic acids and vectors encoding the antibodies or portions thereof, recombinant cells that contain the nucleic acids, and compositions comprising the antibodies or antigen-binding fragments are also disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.

主权项

1. A method of treating cancer in a subject, comprising administering to the subject an immunoconjugate in an amount sufficient to reduce or inhibit the growth of the subject's tumor;
wherein the immunoconjugate comprises an antibody or an antigen binding fragment thereof, and a cytotoxic moiety; wherein the antibody or antigen binding fragment binds specifically to an epitope on OV064 selected from the group consisting of:
i) an epitope comprising amino acid residues selected from amino acid residues 167-176 of OV064,ii) an epitope comprising amino acid residues selected from amino acid residues 177-181 of OV064,iii) an epitope comprising amino acid residues selected from amino acid residues 238-257 of OV064,iv) an epitope recognized by sc77,v) an epitope recognized by sc189,vi) an epitope recognized by sc209,vii) an epitope recognized by 4G10,viii) an epitope recognized by 2F3, andix) an epitope recognized by 3A4; and wherein binding of the immunoconjugate to a cell expressing OV064 induces internalization of the immunoconjugate and OV064 into the cell.