| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide an efficient, simple and non-hazardous process for the preparation of tiotropium bromide (1), tiotropium base (3) and related compounds.SOLUTION: The present invention provides a process for the preparation of scopine ester I or its quaternary salt II, comprising transesterification of scopine or a salt thereof, with a suitable carboxylic ester represented by the formula RCOR.</p> |
