发明名称 |
Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof |
摘要 |
The invention relates generally to activatable antibodies that include a masking moiety (MM), a cleavable moiety (CM), and an antibody (AB) that specifically binds to epidermal growth factor receptor (EGFR), and to methods of making and using these anti- EGFR activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications. |
申请公布号 |
AU2013251310(A1) |
申请公布日期 |
2014.11.06 |
申请号 |
AU20130251310 |
申请日期 |
2013.04.26 |
申请人 |
CYTOMX THERAPEUTICS, INC. |
发明人 |
LOWMAN, HENRY BERNARD;DESNOYERS, LUC ROLAND;LIU, SHOUCHUN;WEST, JAMES WILLIAM;SAGERT, JASON GARY;VASILJEVA, OLGA;MENENDEZ, ELIZABETH-EDNA MARY |
分类号 |
C07K16/28;A61K39/00;C12P21/08 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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