摘要 |
The invention provides a molecule that modulates an activity of a Src family kinase for use in preventing or treating a metastatic cancer a subject. Preferably, the molecule comprises or consists of the structure: Bj-[(Pro)n-Xr-His-Pro-His-Ala-Arg-Ile-Lys]m-Rp, or Bj-[lys-ile-arg-ala-his-pro-his-xr-(pro) n]m-Rp, or a derivative or fragment thereof, wherein B is a first chemical moiety, j is 0 or 1, n is an integer from 1-10, X is any amino acid, r is an integer from 0 to 2, m is an integer from 1 to 3, R is a second chemical moiety, p is 0 or 1, and [lys-ile-arg-ala-his-pro-his-xr-(pro)n ] is the retro-inverso peptide of [(Pro)n-Xr -His-Pro-His-Ala-Arg-Ile-Lys]. |
申请人 |
CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
VAINIKKA, SATU;MORRIS, GEORGE STEVEN;OGUNSALU, SAMUEL;CASTORIA, GABRIELLA;MIGLIACCIO, ANTIMO;AURICCHIO, FERNANDO |