Biocompatible Nanoparticles with Aggregation Induced Emission Characteristics as Fluorescent Bioprobes and Methods of Using the Same for In Vitro and In Vivo Imaging

摘要

The development of fluorescent bioprobes comprising organic fluorescent compounds that exhibit aggregation induced emission (AIE) properties, methods of producing the same, and their practical applications for in vitro and in vivo bioimaging.

主权项

1. A fluorescent bioprobe comprising fluorogen-loaded nanoparticles comprising a fluorogen that exhibits aggregation induced emission properties, wherein the fluorogen comprises one or more chromophores conjugated with one or more aggregation induced emission fluorophores; wherein the fluorogen-loaded nanoparticles have a fluorescence emission; and wherein the fluorogen comprises one or more backbone structures selected from the group consisting of: wherein each R is independently selected from the group consisting of H, alkyl, unsaturated alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and an alkoxy group; and wherein X is one or more chromophores which can conjugate with one or more fluorophores.