SYSTEMS AND METHODS FOR IDENTIFYING SIGNIFICANTLY MUTATED GENES

摘要

A method for identifying significantly mutated genes includes determining a false discovery rate for each of the genes. The method can include estimating local mutation rates for the genes by converting each covariate to a centered and normalized score. The method can also include estimating a local background mutation rate for each of the genes, which can be estimated from silent and/or noncoding mutations of each of the genes itself. In some embodiments, the local background mutation rate is estimated additionally from one or more neighbor genes in a covariate space. Related systems, techniques, and articles are also described.