USE OF TAENIA SOLIUM RECOMBINANT CALRETICULIN FOR INDUCING INTERLEUKIN-10 EXPRESSION

摘要

The invention relates to the use of a recombinant protein in order to induce the expression of interleukin 10, in which the protein is recombinant calreticulin of the parasite Taenia solium (rTsCRT) formulated in a physiological glucose solution administered orally or parenterally. The methodology used for the expression and purification of the rTsCRT as described in the present invention resulted in a recombinant protein expressed without post-transduction modifications, which has immune regulation effects and can stimulate the transcription levels of the mRNA that code for cytokines IL-4 and IL-10. The rTsCRT was expressed in an unlabelled E. coli system, although it can be applied to any expression system, whether in prokaryotic or eukaryotic cells. The rTsCRT is produced so that it can be used for the treatment of local and systemic inflammatory diseases.