HETEROCYCLIC AMIDE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME

摘要

The present invention aims to provide a novel compound having a TRPA1 antagonist activity, and a medicament containing the compound. Moreover, the present invention aims to provide a TRPA1 antagonist and a medicament useful for the prophylaxis or treatment of diseases involving TRPA1.;A medicament containing a compound represented by the formula (I):;;wherein each symbol is as defined in the DESCRIPTION, or a pharmaceutically acceptable salt thereof, and the like.

主权项

1. A medicament, comprising a compound represented by formula (I):wherein
Ar1 is a C6-10 aryl group optionally having substituent(s), a C1-9 heteroaryl group optionally having substituent(s), or a C3-7 cycloalkyl group optionally having substituent(s); Ar2 is a C6-10 aryl group optionally having substituent(s), a C1-9 heteroaryl group optionally having substituent(s), or a C3-7 cycloalkyl group optionally having substituent(s); partial structure (1)is a divalent group of a 5-membered heteroaromatic ring (ring A) containing 1 to 4 hetero atoms selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom, and optionally having 1-3 substituents;
W is C(Rb)(Rc) or a single bond; X is C(Rd)(Re), a sulfur atom, or a single bond; Y is C(Rf) (Rg) or a single bond; when any two of W, X and Y are single bonds, the remaining one is not a single bond; Rb, Rc, Rd, Re, Rf, and Rg are the same or different and each is a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a halogeno-C1-6 alkyl group, a C1-6 alkoxy group, a hydroxyl group, a halogeno-C1-6 alkoxy group, an amino group, an amino group mono- or di-substituted by a C1-6 alkyl group, or a halogeno group; or respective Rb, Rc, Rd, Re, Rf, and Rg on adjacent carbon atoms are optionally joined to form a double bond and/or a ring; R1 is a hydrogen atom, a hydroxyl group, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a halogeno-C1-6 alkyl group, a cyclic C3-6 alkyl group, or a C1-6 alkyl group substituted by a cyclic C3-6 alkyl group; R2 and R3 are the same or different and each is a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, a cyclic C3-6 alkyl group (optionally containing a hetero atom in the ring), a C6-10 aryl group optionally having substituent(s), a C1-9 heteroaryl group optionally having substituent(s), a C1-6 alkyl group substituted by a hydroxyl group, a C1-6 alkyl group substituted by a C6-10 aryl group optionally having substituent(s), or a C1-6 alkyl group substituted by a C1-9 heteroaryl group optionally having substituent(s); and R4 is a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, or a C2-6 alkynyl group, or a pharmaceutically acceptable salt thereof.