VITAMIN B6 DERIVATIVES OF NUCLEOTIDES, ACYCLONUCLEOTIDES AND ACYCLONUCLEOSIDE PHOSPHONATES

摘要

Provided herein are compounds, compositions, and methods of using them to treat infections, neoplastic disease, inflammatory disease, and pain. Such compounds are nucleotides, acyclonucleotides, and ANP phosphonates conjugated with forms and/or moieties of Vitamin B6 for delivery past the cell membrane and into the cell.

主权项

1. A compound having the general structure: wherein R1 is a 5′-nucleosidyl or acyclonucleosidyl residue compound having anticancer, antiviral, antiparasitic or antiinflammatory activity; X and Y are independently O, S, or N; and R2 and R3 are independently chosen from the group consisting of H, phenyl, alkyl, aryl, heteroaryl, and a vitamin B6 moiety having one of the structures wherein at least one of R2 and R3 is a vitamin B6 moiety.