发明名称 |
Pharmaceutical Compositions |
摘要 |
Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. |
申请公布号 |
US2014328930(A1) |
申请公布日期 |
2014.11.06 |
申请号 |
US201414151185 |
申请日期 |
2014.01.09 |
申请人 |
Alpharma Pharmaceuticals, LLC |
发明人 |
Liang Alfred;Stauffer Joseph;Jones James |
分类号 |
A61K9/16;A61K31/485 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
|
主权项 |
1. A multi-layer pharmaceutical composition comprising an antagonist in a first layer and an agonist in a second layer upon said first layer such that the antagonist is substantially sequestered when administered to a human being in an intact form, such that physical disruption of the dosage form decreases the euphoric effect of the agonist when administered to a person as compared to an immediate release agonist composition. |
地址 |
Bridgewater NJ US |