| 摘要 |
The present invention relates to a peptide inhibiting a matrix metalloproteanases activity and use thereof. The peptide inhibiting a matrix metalloproteanases activity exhibits an excellent efficacy of improving the condition of skin by directly inhibiting the matrix metalloproteanases activity. In addition, a composition containing the peptide of the invention has excellent bioactivities of inhibiting the activity of hyaluronic acid degrading enzymes, adipogenesis in fat cells, angiogenesis, and the like, thereby being useful for the treatment of various disease such as anti-obesity, anti-cancer, anti-inflammation, and the like, and skin permeability is excellent due to the small size of the peptide, thereby being useful in various fields. The peptide of the invention having excellent activity and safety can be advantageously applied to drugs, quasi-drugs, and cosmetics. |
| 主权项 |
1. A peptide comprising the amino acid sequence represented by the following formula 1:
Xaa1-Xaa2-Pro-Cys-Xaa3-Xaa4-Xaa5-Ser-Xaa6 [Formula 1] wherein Xaa1 represents Ser, Met, Tyr, Gly, Ala, Val, Leu or Ile, Xaa2 represents Ile, Leu, Val, Ser, Met, Tyr, Gly or Ala, Xaa3 represents Lys, Tyr or Phe, Xaa4 represents Leu, Ile, Val, Ser, Met, Tyr, Gly or Ala, Xaa5 represents Gln, Ser or Thr, Xaa6 represents Gly, Pro or Lys. |
