Stoppers used in pre-filled syringes

摘要

A stopper (12) adapted for attachment with a plunger rod for use within a syringe barrel is disclosed. The stopper includes a main body (26) defining an open rearward end and a closed front end (30). The open rearward end is adapted to receive a front forward end attachment portion of the plunger rod. The stopper (12) also includes a core member (32) integrally formed with the main body (26) adjacent the closed front end (30). The core member (32) includes a nose portion (34) having a conical tip configured for entering an outlet opening of the syringe barrel. The closed front end of the stopper has a profile configured to cooperate with an internal surface of the syringe barrel wall to prevent reflux and reduce dead space within the barrel.