ANTI-INTEGRIN BETA-1 ANTIBODY COMPOSITIONS AND METHODS OF USE THEREOF

摘要

The current invention provides human variable chain framework regions and humanized antibodies comprising the framework regions, the antibodies being specific for integrin β1. The invention also provides methods for utilizing the antibodies, for example to treat diseases such as cancer.

主权项

1. A humanized antibody which specifically binds integrin β1 comprising a heavy chain variable (VH) region and a light chain variable (VL) region, wherein the VH region has less than about 97%, 96% or 95% identity to a VH region having an amino acid sequence as set forth in SEQ ID NO:2, and wherein the VL region has less than about 97%, 96% or 95% identity to a VL region having an amino acid sequence as set forth in SEQ ID NO:4.