| 主权项 |
1. A compound of the formula: or a pharmaceutically acceptable salt thereof, where represents a double or single covalent bond, and the group contains 0 or 1 double bonds; R1 is —NR10R11, —(C═O)NR10R11, —(C═S)NR10R11, —(C═O)R12, —SO2R12, —(C═O)OR12, —O(C═O)R12, —OR12, or —N(C═O)R12, or R2 is hydrogen, C1-C6alkyl, C3-C7cycloalkyl, heterocycloalkyl, (aryl)C0-C4alkyl, or R1 and R2 are taken together to form an optionally substituted 5- to 7-membered heterocyclic ring containing 0 or 1 additional N, S, or O atoms, or an optionally substituted 5- to 7-membered heterocyclic ring containing 0 or 1 additional N, S, or O atoms fused to an optionally substituted 5- to 7-membered carbocyclic or heterocyclic ring; R3, R4, R5, R6, R7, and R8 are independently
(a) hydrogen, halogen, or amino, or(b) C1-C6alkyl, C2-C6alkenyl, (C3-C7cycloalkyl)C0-C4alkyl, (C3-C7cycloalkenyl)C0-C4alkyl, (heterocycloalkyl)C0-C4alkyl, C2-C6alkanoyl, or mono- or di-C1-C6alkylamino, each of which is optionally substituted; or R3 and R4 may be joined to form an optionally substituted 3- to 7-membered cycloalkyl ring or an optionally substituted 3- to 7-membered heterocycloalkyl ring containing 1 or 2 heteroatoms independently chosen from N, S, and O; R5 and R6 may be joined to form an optionally substituted 3- to 7-membered cycloalkyl ring or an optionally substituted 3- to 7-membered heterocycloalkyl ring containing 1 or 2 heteroatoms independently chosen from N, S, and O; R7 and R8 may be joined to form an optionally substituted 3- to 7-membered cycloalkyl ring or an optionally substituted 3- to 7-membered heterocycloalkyl ring containing 1 or 2 heteroatoms independently chosen from N, S, and O; or R5 is a C7-C11 saturated or unsaturated hydrocarbon chain that is (i) covalently bound to R7, where R7 is a methylene group or R5 is a C7-C11 saturated or unsaturated hydrocarbon chain that is (ii) covalently bound to an optionally substituted cycloalkyl ring formed by R7 and R8 being joined to from a 3- to 7-membered optionally substituted cycloalkyl ring; and R6 is hydrogen, C1-C6alkyl, or (C3-C7cycloalkyl)C0-C2alkyl; T is a tetrazole group attached via its carbon atom, or T is a group of the formula: R9 is hydroxyl, amino, —COOH, —NR10R11, —OR12, —SR12, —NR10(S═O)R11, —NR10SO2R11, —NR10SONR11R12, —NR10SO2NR11R12, —(C═O)OR10, —NR10(C═O)OR11, or —CONR10R11, or R9 is C1-C6alkyl, C2-C6alkenyl, C2-C6alkanoyl, (C3-C7cycloalkyl)C0-C4alkyl, (C3-C7cycloalkenyl)C0-C4alkyl, (C3-C7cycloalkyl)CH2SO2—, (C3-C7cycloalkyl)CH2SO2NR10—, (heterocycloalkyl)C0-C4alkyl, (aryl)C0-C2alkyl, or (5- to 10-membered heteroaryl)C0-C2alkyl, each of which is optionally substituted, or R9 is a phosphonate of the formulawhere p is 0, 1, or 2;
R9 is RXXC0-C4alkyl-, where X is —(C═O)NH—, —NH(C═O)— and RX is aryl or heteroaryl, or R9 is —CH(RY)(C3-C7cycloalkyl), —SO2CH(RY)(C3-C7cycloalkyl), or —NR10SO2CH(RY)(C3-C7cycloalkyl), where RY is halogen or RY is C1-C6alkyl, C2-C6alkanoyl, (C3-C7cycloalkyl)C0-C4alkyl, (C4-C7cycloalkenyl)C0-C4alkyl, (aryl)C0-C4alkyl, (aryl)C0-C4alkoxy, (heterocycloalkyl)C0-C2alkyl, or (5- to 10-membered heteroaryl)C0-C4alkyl, each of which is optionally substituted; R10, R11, and R12 are independently at each occurrence hydrogen, or C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, (aryl)C0-C2alkyl, (C3-C7cycloalkyl)C0-C2alkyl, (C3-C7cycloalkenyl)C0-C2alkyl, (heterocycloalkyl)C0-C2alkyl, or (5- to 10-membered heteroaryl)C0-C2alkyl, each of which is optionally substituted; R13 is hydrogen or C1-C2alkyl; R14 and R15 are independently hydrogen, hydroxyl, or C1-C2alkyl; n is 0, 1, or 2; M is hydrogen, halogen, hydroxyl, C1-C2alkyl, or C1-C2alkoxy, Y is absent, CR18R19, NR20, S, O, —O(C═O)(NR20)—, NH(C═O)(NR20)—, NH(S═O)(NR20)—, or —O(C═O)—; or Y is taken together with one of J, L, or M to form a ring; J is CH2 or J is taken together with Y to form a 3- to 7-membered carbocyclic or heterocyclic ring, which ring is substituted with 0 or 1 or more substituents independently chosen from halogen, hydroxy, amino, cyano, C1-C2alkyl, C1-C2alkoxy, C1-C2alkoxy, trifluoromethyl, and trifluoromethoxy; when J is taken together with Y to form a ring Z may be absent; L is CH2 or L is taken together with Y to form a 3- to 7-membered carbocyclic or heterocyclic ring, which ring is substituted with 0 or 1 or more substituents independently chosen from halogen, hydroxy, amino, cyano, C1-C2alkyl, C1-C2alkoxy, C1-C2alkoxy, trifluoromethyl, and trifluoromethoxy; when L is taken together with Y to form a ring Z may be absent; Z is (mono- or bicyclic aryl)C0-C2alkyl or (mono- or bicyclic heteroaryl)C0-C2alkyl, each of which Z is substituted with
0 or 1 or more substituents independently chosen from halogen, hydroxyl, amino, cyano, —CONH2, —COOH, —SO2NR11R12, —(C═O)NR11R12, —NR11(C═O)R12, C1-C4alkyl, C2-C4alkanoyl, C1-C4alkoxy, C1-C4alkylthio, mono- and di-C1-C4alkylamino, C1-C4alkylester, C1-C2haloalkyl, and C1-C2haloalkoxy, and0 or 1 (C3-C7cycloalkyl)C0C2alkyl, (phenyl)C0-C2alkyl, (phenyl)C0-C2alkoxy, (5- or 6-membered heteroaryl)C0-C2alkyl, (5- or 6-membered heteroaryl)C0-C2alkoxy, naphthyl, indanyl, (5- or 6-membered heterocycloalkyl)C0-C2alkyl, or 9- or 10-membered bicyclic heteroaryl, each of which is substituted with 0, 1, or 2 substituents independently chosen from:(c) halogen, hydroxyl, amino, cyano, nitro, —COOH, —CONH2, CH3(C═O)NH—, ═NOH, C1-C4alkyl, C1-C4alkoxy, C1-C4hydroxyalkyl, mono- and di-C1-C4alkylamino, —NR8SO2R11, —C(O)OR11, —NR8COR11, —NR8C(O)OR11, trifluoromethyl, and trifluoromethoxy, and(d) phenyl and 5- or 6-membered heteroaryl, each of which is substituted with 0 or 1 or more of halogen, hydroxyl, C1-C4alkyl, and C1-C2alkoxy; R16 represents 0 to 4 substituents is independently chosen at from halogen, C1-C2alkyl, and C1-C2alkoxy; R18 and R19 are independently hydrogen, hydroxyl, halogen, C1-C2alkyl, C1-C2alkoxy, C1-C2haloalkyl, or C1-C2haloalkoxy; and R20 is hydrogen, C1-C2alkyl, C1-C2haloalkyl, or C1-C2haloalkoxy. |
