发明名称 |
Neosaxitoxin Combination Formulations for Prolonged Local Anesthesia |
摘要 |
Since each of the site I sodium channel blockers have a unique activity and cannot be used to extrapolate the same effective dosage for another site I sodium channel blocker, studies were conducted to identify dosages of neosaxitoxin (“NeoSTX”) and bupivacaine, alone or in combination with epinephrine, to provide two to three days of pain relief in humans. Bupivacaine-NeoSTX combinations produce more reliable blockade and longer duration blockade compared to NeoSTX alone. The three-way combination of NeoSTX-bupivacaine-epinephrine produces more prolonged local anesthesia than the two-way combination of NeoSTX-bupivacaine. Addition of epinephrine to this NeoSTX-bupivacaine combination dramatically prolongs the duration of complete blockade to a mechanical stimulus. These results led to development of specific combination dosage formulations. |
申请公布号 |
US2014329841(A1) |
申请公布日期 |
2014.11.06 |
申请号 |
US201414331947 |
申请日期 |
2014.07.15 |
申请人 |
The Children's Medical Center Corporation |
发明人 |
Berde Charles;Kohane Daniel S. |
分类号 |
A61K31/519;A61K31/445;A61K31/137 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Boston MA US |