| 摘要 |
Provided are novel 2-fluorophenyl propionic acid derivatives which have excellent anti-inflammatory/analgesic effects while avoiding side effects such as gastrointestinal disorders, namely 2-fluorophenyl propionic acid derivatives represented by the formula (I) below or pharmaceutically acceptable salts thereof,;;[wherein, R1 represents a hydrogen atom, a halogen atom, or a substituted or unsubstituted phenyl group, X represents —CH2—, —NH—, —O—, or —S—, and Y specifically represents group (II);;(wherein, Z1 represents —CO—, —CH(OH)—, or —CH2—, and n represents an integer of 1 or 2.)] |
| 主权项 |
1. A 2-fluorophenyl propionic acid derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof:wherein,
R1 represents a hydrogen atom, a halogen atom, or a substituted or unsubstituted phenyl group, X represents —CH2—, —NH—, —O—, or —S—, and Y representsgroup (1):wherein, Z1 represents —CO—, —CH(OH)—, or —CH2—, and n represents an integer of 1 or 2, group (2):wherein Z2 represents an oxygen atom or a sulfur atom, orgroup (3):wherein, R2 and R3, which are the same or different, represent a lower alkyl group, with an exception of a case where, simultaneously, R1 is a hydrogen atom, X is —CH2—, Z1 is —CO— or —CH(OH)—, and n is 1. |
