ANTI-CD38 ANTIBODIES AND FUSIONS TO ATTENUATED INTERFERON ALPHA-2B
摘要
<p>Antibodies that specifically bind to CD38, as well as constructs comprising such antibodies fused to attenuated interferon alpha-2B proteins are provided. Anti-CD38-attenuated interferon alpha-2b fusion constructs may be used to inhibit proliferation in cancerous cells that express both CD38 and the receptor for IFN-alpha2b, as well as to induce apoptosis in such cells. Inhibition of proliferation and induction of apoptosis in cancerous cells may serve as the basis for the treatment of the underlying cancer.</p>
申请公布号
CA2909952(A1)
申请公布日期
2014.11.06
申请号
CA20132909952
申请日期
2013.04.29
申请人
TEVA PHARMACEUTICALS AUSTRALIA PTY LTD.
发明人
CLARKE, ADAM W.;POLLARD, MATTHEW;DOYLE, ANTHONY G.;BEHRENS, COLLETTE;YAMAGISHI, TETSUO;WILSON, DAVID S., JR.;POGUE, SARAH L.;TAURA, TETSUYA