| 发明名称 |
ANTIBODIES, VARIABLE DOMAINS & CHAINS TAILORED FOR HUMAN USE |
| 摘要 |
The invention relates to the provision of antibody therapeutics and prophylactics that are tailored specifically for human use. The present invention provides libraries, vertebrates and cells, such as transgenic mice or rats or transgenic mouse or rat cells. Furthermore, the invention relates to methods of using the vertebrates to isolate antibodies or nucleotide sequences encoding antibodies. Antibodies, heavy chains, polypeptides, nucleotide sequences, pharmaceutical compositions and uses are also provided by the invention. |
| 申请公布号 |
US2014331343(A1) |
申请公布日期 |
2014.11.06 |
| 申请号 |
US201313875892 |
申请日期 |
2013.05.02 |
| 申请人 |
Kymab Limited |
发明人 |
Bradley Allan;Friedrich Glenn;Lee E-Chiang;Strivens Mark;England Nicholas |
| 分类号 |
C07K16/18 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A non-human vertebrate or a vertebrate cell whose genome comprises an immunoglobulin (Ig) heavy (H) chain locus comprising human Ig gene segment JH6-02, one or more VH gene segments and one or more D gene segments upstream of a constant (C) region; wherein the gene segments in said H chain locus are operably linked to a constant region, wherein said vertebrate is functional to express an IgH chain produced by recombination of said human JH6-02 with a D segment and a VH segment. |
| 地址 |
unknown |
