SYSTEMS MEDICINE PLATFORM FOR PERSONALIZED ONCOLOGY

摘要

The present invention is directed to a platform (e.g., Web-based) that enables basic and clinical research activities by integrating patient characteristics and clinical outcome data with a variety of high-throughput research data in a unified environment. While several rich data repositories for high dimensional research data exist in the public domain, most focus on a single data type and do not support integration across multiple technologies. The present invention in at least one embodiment includes a broad collection of bioinformatics and systems biology tools for analysis and visualization of four major “omics” types: DNA, mRNA, microRNA, and metabolites, as well as next-generation sequencing. The present invention helps facilitate systems medicine by providing easy identification of trends and patterns in integrated datasets and hence facilitate the use of better targeted therapies for cancer.

主权项

1. A method for providing data relating to cancer, the method comprising:
(a) receiving, into a processing device, raw data of a plurality of data types selected from the group consisting of mRNA expression data, miRNA expression data, metabolomics data, DNA copy number data, and next-generation sequencing; (b) in the processing device, normalizing the raw data into normalized data of a single data type; (c) storing the normalized data in a database; (d) receiving a query for the data from a device used by a user into the database; (e) performing the query through the normalized data in the database to locate the data; and (f) outputting the data from the database to the device used by the user.