Framework for Modeling a Clinical Trial Study Using a Cross-Over Treatment Design

摘要

The present disclosure provides for modeling a clinical trial study, which may implement a cross-over design. A plurality of treatments is generated for a clinical trial study, based on a first subset of operational parameters. A plurality of sequences is also generated for the clinical trial study, based on a second subset of the operational parameters. Each sequence of the plurality of sequences comprises a combination of ones of the plurality of treatments. A plurality of subject groups is assigned to the plurality of sequences, where one subject group of the plurality of subject groups is respectively assigned to one sequence of the plurality of sequences. The one sequence is administered to subjects of the one subject group during the clinical trial study.

主权项

1. A method comprising:
generating a plurality of treatments for a clinical trial study, wherein
the generating the plurality of treatments is based on a first subset of operational parameters; generating a plurality of sequences for the clinical trial study, wherein
the generating the plurality of sequences is based on a second subset of the operational parameters, andeach sequence of the plurality of sequences comprises a combination of ones of the plurality of treatments; and assigning a plurality of subject groups to the plurality of sequences, wherein
one subject group of the plurality of subject groups is respectively assigned to one sequence of the plurality of sequences, andthe one sequence is administered to subjects of the one subject group during the clinical trial study.