发明名称 |
CHARGE TRIGGERING OF SELF-ORGANIZED NANOPARTICLES |
摘要 |
The present application discloses a nanoparticle comprising compounds of the formula A-B-C(-D), wherein A designates an anchoring moiety having self-organizing properties in relation to the nanoparticle; B designates a cleavable linker; C designates an anionic moiety having a net charge of at least −2 at pH 6.0; and D, which is optional, designates a polymer moiety which induces long circulating properties of the nanoparticle in mammalian tissue; and wherein the average net charge of the compounds is at least −1 at pH 6.0. The application also discloses the individual compounds of the formula A-B-C(-D) as well as a drug delivery system comprising the self-organized nanoparticle having included in the interior thereof one or more pharmaceutically active agents and/or diagnostically relevant species, and a method of treating a cancerous or inflammatory condition in a mammal, involving the administration of the drug delivery system to the mammal. |
申请公布号 |
US2014328897(A1) |
申请公布日期 |
2014.11.06 |
申请号 |
US201214117881 |
申请日期 |
2012.05.16 |
申请人 |
Jølck Rasmus Irming;Henriksen Jonas Rosager;Gjetting Torben;Andresen Thomas Lars |
发明人 |
Jølck Rasmus Irming;Henriksen Jonas Rosager;Gjetting Torben;Andresen Thomas Lars |
分类号 |
A61K47/48;A61K31/282;A61K31/7088 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
1. A nanoparticle comprising as a constituent thereof a plurality of compounds of the formula A-B-C(-D), wherein
A designates an anchoring moiety having self-organizing properties in relation to the nanoparticle; B designates a cleavable linker; C designates an anionic moiety having a net charge of at least −2 at pH 6.0; and D, which is optional, designates a polymer moiety which induces long circulating properties of the nanoparticle in mammalian tissue;and wherein the average net charge of the compounds is at least −1 at pH 6.0. |
地址 |
Valby DK |