发明名称 |
DEVICES, SYSTEMS AND METHODS FOR OPTOGENETIC MODULATION OF ACTION POTENTIALS IN TARGET CELLS |
摘要 |
Aspects of the disclosure include devices, systems and methods for optogenetic modulation of action potentials in target cells. The subject devices include light-generating devices, control devices, and delivery devices for delivering vectors to target cells. The subject systems include light-activated proteins, response proteins, nucleic acids comprising nucleotide sequences encoding these proteins, as well as expression systems that facilitate expression of these proteins in target cells. Also provided are methods of using the subject devices and systems to optogenetically inhibit and intercept action potentials in target cells, e.g., to treat a neurological or psychiatric condition in a human or non-human animal subject. |
申请公布号 |
WO2014179331(A2) |
申请公布日期 |
2014.11.06 |
申请号 |
WO2014US35900 |
申请日期 |
2014.04.29 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;HUMBOLDT-UNIVERSITAT ZU BERLIN |
发明人 |
DEISSEROTH, KARL, A.;FERENCZI, EMILY, ANNE;HEGEMANN, PETER |
分类号 |
A61K48/00;C12N15/85 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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