| 主权项 |
1. A Compound of the formula (I) or a pharmaceutically acceptable salt thereof, Wherein: Ar is selected from the group consisting of optionally substituted or unsubstituted aryl and heteroaryl, when substituted, the substituents independently selected from halogen, alkyl, haloalkyl, or hydroxylalkyl; L is H, optionally substituted or unsubstituted alkyl, optionally substituted or unsubstituted cycloalkyl, optionally substituted or unsubstituted cycloalkylalkyl, optionally substituted or unsubstituted aryl, optionally substituted or unsubstituted arylalkyl, optionally substituted or unsubstituted sulfonamido, optionally substituted or unsubstituted heterocycloalkyl, optionally substituted or unsubstituted heterocycloalkylalkyl, optionally substituted or unsubstituted heteroaryl, or optionally substituted or unsubstituted heteroarylalkyl; when substituted, the substituents can be one or more groups independently selected from the group consisting of halo, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, amino, aminoalkyl, amido, aminocarbonyl, sulfonamido, ureido, cyano, acetyl, acyl, carboxylic acid, hydroxyl, hydroxylalkyl, alkoxyl, —NHalkylhydroxyl, —NHalkoxyalkyl, —NHalkylamnio, —NHcycloalkyl, —NHcycloalkylalkyl, —N Hheterocycloalkyl, —NH heterocycloalkylalkyl, —NHaryl, —NHarylalkyl, —NHheteroaryl, or —NHheteroarylalkyl; Y is O, S, NR2R2′ or a direct bond; X1, X2, X3 and X4 are independently N or CR1; R1 is H, or —Y-L; R, R2, and R2′ are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, haloalkoxyl, hydroxyl, amino, aminocarbonyl, sulfonamido, cyano, alkynyl, alkoxyl, aryloxyl, carboxylic acid, carboxylic ester or halogen, or R2, R2′ together with the nitrogen atom to which they are attached, formed a 3- to 7-membered heterocycloalkyl ring, and the hetero atom could be selected from at least one of O, S or N atoms, the 3- to 7-membered heterocycloalkyl ring could be further optionally substituted with a group independently selected from alkyl, cycloalkyl, methylsulfonyl, ureido, acyl, amido, aminocarbonyl, alkylamino, alkylhydroxyl, heterocycloalkyl, aryl, or heteroaryl. |
