| 发明名称 |
Hydrazine-based and carbonyl-based bifunctional crosslinking reagents |
| 摘要 |
<p>Reagents and methods are provided for crosslinking and immobilizing biomolecules, drugs and synthetic polymers. The reagents of forumula VII or VIII possess (i) a thiol or amino reactive group; and (ii) a oxyamino moiety. Conjugates and immobilized biomolecules are also provided.
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒB-R-ONH 2 €¢HX€ƒ€ƒ€ƒ€ƒ€ƒVII;
or
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒB-R-ON=C(R 1 R 2 )€ƒ€ƒ€ƒ€ƒ€ƒVIII</p> |
| 申请公布号 |
EP2295407(B1) |
申请公布日期 |
2014.11.05 |
| 申请号 |
EP20100184127 |
申请日期 |
2001.03.22 |
| 申请人 |
SOLULINK, INC. |
发明人 |
SCHWARTZ, DAVID, A. |
| 分类号 |
C07D207/46;C07H21/02;A61K47/48;C07D207/44;C07D207/452;C07D213/82;C07D401/12;C07F7/18;C07H21/04;C07K1/107;C07K14/06;C07K17/06;C07K17/14;C08G65/329;C08G65/336;C12N9/96;C12N11/06;C12N11/14 |
主分类号 |
C07D207/46 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
