发明名称 |
PEPTIDE-LIPID CONSTRUCTS AND THEIR USE IN A FC-FUNCTION ASSAY |
摘要 |
The present invention discloses a method of assaying Fc-function in an immunoglobulin containing sample by contacting the sample, in the presence of a complement, with red blood cells modified to incorporate a F-S-L peptide-lipid construct. The F-S-L peptide construct comprises a functional group (F) that is a target antigen for a complement activating immunoglobulin, a spacer group (S) covalently linking F to L and a lipid group (L). The present invention further discloses a specific construct, DOPE-Ad-CMG(2)-hCMV2 where the F group is an antigen of cytomegalovirus, that is used in assaying the Fc function of an intravenous immunoglobulin (IVIG) product. |
申请公布号 |
EP2681559(A4) |
申请公布日期 |
2014.11.05 |
申请号 |
EP20120753030 |
申请日期 |
2012.03.05 |
申请人 |
KODE BIOTECH LIMITED |
发明人 |
HENRY, STEPHEN MICHEAL;KOMARRAJU, VENKATA SARVANI |
分类号 |
G01N33/555;A61K31/683;A61K38/16;A61K39/385;C07F9/10;C07K14/00;C07K14/045;C07K17/06;G01N33/53;G01N33/531;G01N33/536;G01N33/68 |
主分类号 |
G01N33/555 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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