发明名称 |
PROCESS FOR PRODUCING WATER-SOLUBLE MODIFIED HYALURONIC ACID |
摘要 |
The present invention provides a water-soluble modified HA practically used as a drug carrier and a production method thereof. The present invention provides: a water-soluble modified hyaluronic acid, the residence time in blood of which is elongated to a practical level, which is produced by introducing a substituent into the carboxy group of the glucuronic acid of hyaluronic acid or a derivative thereof, via an amide bond, at a lower limit of an introduction rate of 5 mole % or more, using a BOP condensing agent in an aprotic polar solvent; and a production method thereof. Moreover, by cross-linking the modified hyaluronic acid, the present invention provides a hyaluronic acid gel capable of extremely long drug sustained-release even at the same cross-linking functional group introduction rate as that of the conventionally known gel. |
申请公布号 |
EP1790665(B1) |
申请公布日期 |
2014.11.05 |
申请号 |
EP20050782114 |
申请日期 |
2005.09.07 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
YASUGI, KENJI;NAKAMURA, TERUO;SHIMOBOJI, TSUYOSHI;SATO, MIKA |
分类号 |
C08B37/00;A61K47/48;C08J3/075;C08J3/12;C08L5/08 |
主分类号 |
C08B37/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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