发明名称 |
PREPARATION METHOD OF 3,7,11-TRIMETHYLDODEC-2,4,6,10-TETRAENE-1-YL PHOSPHONIC SALT |
摘要 |
<p>Provided in the present invention is a preparation method for a phosphonic salt, comprising the step of: reacting 3,7,11-trimethyldodec-1,4,6,10-tetraene-3-ol with triarylphosphine and an acid in an alcohol solvent at 50-100°C to form the phosphonic salt, wherein the acid is a sulfamic acid or methanesulfonic acid, and the alcohol solvent is a straight chain monohydric alcohol containing 1-5 carbon atoms. The method is performed in nearly neutral conditions, greatly reducing the generation of impurities and greatly obtaining phosphonic salt with an increased E content. The yield of lycopene obtained by using the phosphonic salt as a raw material is high.</p> |
申请公布号 |
EP2799440(A1) |
申请公布日期 |
2014.11.05 |
申请号 |
EP20120861708 |
申请日期 |
2012.12.10 |
申请人 |
NANJING UNIVERSITY OF TECHNOLOGY;ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY |
发明人 |
LV, CHUNLEI;PI, SHIQING;CHEN, JIANHUI;LU, DINGQIANG;OUYANG, PINGKAI |
分类号 |
C07F9/54 |
主分类号 |
C07F9/54 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|