发明名称 |
MATERIALS AND METHODS FOR DIAGNOSIS, PROGNOSIS, MONITORING OF RECURRENCE, AND ASSESSMENT OF THERAPEUTIC/PROPHYLACTIC TREATMENT OF PANCREATOBILIARY CANCER |
摘要 |
A method of detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract or inferring an increased risk thereof, comprising obtaining a sample of pancreatobiliary cells from a patient with a set of detectably labeled probes comprising a locus-specific probe for MCL1 (myeloid cell leukemia sequence 1), a locus-specific probe for EGFR (epidermal growth factor receptor), a locus-specific probe for MYC, and a locus-specific probe for P16 under hybridization conditions and determining the presence of chromosomal abnormalities; a set of probes comprising a locus-specific probe for MCL1, a locus-specific probe for EGFR, a locus-specific probe for MYC, and a locus-specific probe for P16; and a kit comprising the set of probes and instructions for detecting high-grade dysplasia, pancreatobiliary cancer, or metastatic cancer to the pancreatobiliary tract, or inferring an increased risk thereof, in a patient. |
申请公布号 |
EP2798080(A1) |
申请公布日期 |
2014.11.05 |
申请号 |
EP20120806870 |
申请日期 |
2012.12.20 |
申请人 |
ABBOTT MOLECULAR INC.;MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH |
发明人 |
SOKOLOVA, IRINA;MORRISON, LARRY;PESTOVA, EKATERINA;FRITCHER, EMILY, BARR;ROBERTS, LEWIS;GORES, GREGORY;HALLING, KEVIN;KIPP, BENJAMIN |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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