发明名称 |
TARGET MOLECULE TO WHICH AMYLOSPHEROID BINDS AND INDUCES MATURE NEURONAL CELL DEATH, METHOD AND SUBSTANCE FOR INHIBITING AMYLOSPHEROID-INDUCED NEURONAL CELL DEATH, AND USES FOR SAID TARGET MOLECULE, METHOD, AND SUBSTANCE |
摘要 |
<p>In one or a plurality of embodiments, there is provided a target molecule of amylospheroid, which is expressed in mature neurons and to which the amylospheroid binds to induce death of cells. Further, in one or a plurality of embodiments, there is provided a method and a substance for inhibiting death of mature neurons induced by the amylospheroid. In one aspect, the present disclosure relates to a use of Na + /K + -ATPase ±3 as a binding target molecule of amylospheroid. In another aspect, the present disclosure relates to a method for suppressing death of mature neurons induced by the amylospheroid, including inhibiting protein-protein interaction between the amylospheroid and the Na + /K + -ATPase ±3, and the like.</p> |
申请公布号 |
EP2799542(A1) |
申请公布日期 |
2014.11.05 |
申请号 |
EP20120862008 |
申请日期 |
2012.12.21 |
申请人 |
TAO HEALTH LIFE PHARMA CO., LTD. |
发明人 |
HOSHI, MINAKO |
分类号 |
C12N15/09;A61K31/7088;A61K38/00;A61K45/00;A61P25/28;C07K14/00;C12N9/16;C12Q1/42;G01N33/15;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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