发明名称 |
BINDING MOLECULES SPECIFIC FOR HER3 AND USES THEREOF |
摘要 |
The present invention relates to antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life. In addition, the invention provides compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction. |
申请公布号 |
EP2797957(A1) |
申请公布日期 |
2014.11.05 |
申请号 |
EP20120852317 |
申请日期 |
2012.11.20 |
申请人 |
MEDIMMUNE, LLC |
发明人 |
CHOWDHURY, PARTHA S.;TICE, DAVID;XIAO, ZHAN;STEINER, PHILIPP;KINNEER, KRISTA;REBELATTO, MARLON |
分类号 |
C07K16/40;A61K39/395;A61P35/00 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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