发明名称 |
Porous polymer scaffolds for neural tissue engineering and methods of producing the same |
摘要 |
The present invention relates to scaffolds that can physically guide cells, e.g. neurons, while best matching the material properties of native tissue. The present invention also relates to methods of generating such scaffolds, and for the use of such scaffolds, e.g. in spinal cord and peripheral nerve injury repair. The methods of the present invention include a uniquely controlled freeze casting process to generate highly porous, linearly oriented scaffolds. The scaffolds of the present invention not only comprise a highly aligned porosity, but also contain secondary guidance structures in the form of ridges running parallel to the pores to create a series of microstructured and highly aligned channels. This hierarchy of structural guidance aligns and guides neurite outgrowth down the channels created by the ridges, and keep neurites from branching perpendicular to the inter-ridge grooves. |
申请公布号 |
US8877498(B2) |
申请公布日期 |
2014.11.04 |
申请号 |
US201113309280 |
申请日期 |
2011.12.01 |
申请人 |
Drexel University |
发明人 |
Wegst Ulrike G.K.;Wheatley Margaret;Riblett Benjamin W.;Francis Nicola;Donius Amalie Elizabeth |
分类号 |
C12N5/00;C12N5/0793 |
主分类号 |
C12N5/00 |
代理机构 |
Saul Ewing LLP |
代理人 |
Saul Ewing LLP ;Doyle Kathryn;Landry Brian R. |
主权项 |
1. A scaffold for supporting cell growth, the scaffold comprising regions of aligned pores, wherein at least some walls of the pores include ridges that protrude from the walls and run parallel to a long axis of the pores. |
地址 |
Philadelphia PA US |